Feb 18, Peyronie's disease is one form of erectile dysfunction where it can be difficult to get or maintain an erection. Men who have Peyronie's disease. Peyronie's disease is where plaques (segments of flat scar tissue) form under the skin of the penis. These plaques can cause the penis to bend or become. Dec 5, Peyronie's disease is a curve in the penis. Many men have a slight curve in the penis. As long as there is no pain or problem with sexual.