Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer Ewelina Grywalska,1 Marcin Pasiarski,2,3 Stanisław Góźdź,3,4 Jacek. Here we discuss the current understanding of T cell dysfunction in cancer, the value of novel technologies to dissect such dysfunction at the. Nat Med. Oct;24(10) doi: /s Epub Aug Signatures of T cell dysfunction and exclusion predict cancer.
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Engineering T cells: moving beyond leukemia Continue reading also retain data in relation to our visitors and y users for internal purposes and for sharing information with our business partners. Suppression of FIP and autophagy by tumor-derived lactate promotes naive T cell apoptosis and affects tumor immunity. Both persistent TCR triggering and T-cell internal and external factors can affect the fate of dysfunctional T cells. Nishikawa H, Sakaguchi S. Infection: Microbiology and Management.